1. 基本信息

郑以，男，1988年9月生，四川雅安人，九三学社社员，博士，副教授，硕士生导师。2010年6月毕业于四川农业大学3344体育在线官网动物科学专业，获农学学士学位；2013年6月毕业于西北农林科技大学3344体育在线官网动物遗传育种与繁殖专业，获农学硕士学位；2018年2月毕业于荷兰阿姆斯特丹大学医学院生殖医学与生物学专业，获医学博士学位。2018年2月起任职于西北农林科技大学3344体育在线官网，从事教学科研工作。

2. 研究方向

生殖生物学和干细胞生物学。主要从事雄性生殖相关基础和转化研究，重点研究精子发生和生殖干细胞。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、陕西省自然科学基础研究计划青年项目等，入选“陕西省高校科协青年人才托举计划”。以（含共同）第一或通讯作者在领域主流期刊如Human Reproduction Update、Journal of Biological Chemistry、Journal of Animal Science and Biotechnology、Molecular Human Reproduction、Reproduction等发表论文20余篇。现为中国畜牧兽医学会高级会员、欧洲人类生殖与胚胎学学会（ESHRE）会员、国际生殖研究学会（SSR）会员，担任Frontiers in Genetics主题编辑（Topic Editor）、Frontiers in Endocrinology评审编辑（Review Editor），以及iScience、Theriogenology、Reproduction Fertility and Development、Frontiers in Cell and Developmental Biology等期刊审稿人。

3. 开设课程

本科生：《细胞生物学》（双语）

研究生：《动物繁殖理论与生物技术》《动物繁殖生理与胚胎工程》

4. 主持项目

（1）国家自然科学基金青年项目，32002178，LncRNA-106504875介导ZBTB16调控猪精原干细胞自我更新的分子机制，2021.01-2023.12，24万元，在研，主持

（2）陕西省引进国外博士专项，F2020221006，猪精子发生过程中基因组三维结构的动态变化，2021.01-2023.12，22.5万元，在研，主持

（3）西北农林科技大学基本科研业务费，DK202104，维甲酸诱导的猪精原干细胞分化与减数分裂进程及其调控网络的构建，2021.06-2022.06，4万元，在研，主持

（4）中国博士后科学基金面上项目一等资助，2018M641032，SMC5/6复合物在精原干细胞增殖与分化中的作用及其机制，2019.01-2020.12，8万元，在研，主持

（5）陕西省自然科学基础研究计划一般项目（青年），2019JQ-430，SMC5/6复合物维持小鼠精原干细胞基因组稳定性的机制研究，2019.01-2020.12，3万元，结题，主持

（6）陕西省高校科协青年人才托举计划项目，20180204，猪精原干细胞增殖与分化关键基因和分子标记的筛选，2019.01-2020.12，1万元，结题，主持

（7）畜禽遗传资源发掘与创新利用四川省重点实验室开放课题，SNDK-KF-201804，猪精子发生过程中基因组三维结构的动态变化，2019.01-2020.12，3万元，在研，主持

（8）西北农林科技大学博士科研启动基金，2452018037，猪精子发生过程中转录组和染色质动态变化分析，2018.04-2021.02，20万元，结题，主持

5. 发表论文（第一/通讯作者）

（1）Callista L Mulder#, Yi Zheng#, Sabrina Z Jan, Robert B Struijk, Sjoerd Repping, Geert Hamer*, Ans M M van Pelt. Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. Human Reproduction Update. 2016, 22(5): 561-73. (#共同一作，IF=17.179，中科院1区，Top期刊)

（2）Xueni You#, Tianjiao Li#, Youjie Cui, Wei Liu, Zechao Cheng, Wenxian Zeng, Peng Wang*, Yi Zheng*. Retinoic acid-induced differentiation of porcine prospermatogonia in vitro. Theriogenology. 2023, 198: 344-55. (*通讯作者，IF=2.923，中科院2区，Top期刊)

（3）Tianjiao Li#, Yi Zheng#, Zhili Wu, Ming Guo, Ruifang Liu, Wenxian Zeng*, Yinghua Lv*. YTHDF2 controls hexavalent chromium-induced mitophagy through modulating Hif1α and Bnip3 decay via the m6A/mRNA pathway in spermatogonial stem cells/progenitors. Toxicology Letters. 2023, 377: 38-50. (#共同一作，IF=4.271)

（4）Yi Zheng#, Lingkai Zhang#, Long Jin#, Pengfei Zhang#, Fuyuan Li, Ming Guo, Qiang Gao, Yao Zeng, Mingzhou Li*, Wenxian Zeng*. Unraveling three-dimensional chromatin structural dynamics during spermatogonial differentiation. Journal of Biological Chemistry. 2022, 298(2): 101559. (IF="5.486，中科院2区，自然指数期刊、Top期刊)

（5）Yi Zheng#, Qiang Gao#, Tianjiao Li, Ruifang Liu, Zechao Cheng, Ming Guo, Jinhong Xiao, De Wu, Wenxian Zeng*. Sertoli cell and spermatogonial development in pigs. Journal of Animal Science and Biotechnology. 2022, 13: 45. (IF="6.175，中科院1区，Top期刊)

（6）Ruifang Liu#, Zidong Liu#, Ming Guo, Wenxian Zeng*, Yi Zheng*. SETDB1 regulates porcine spermatogonial adhesion and proliferation through modulating MMP3/10 transcription. Cells. 2022, 11(3): 370. (*通讯作者，IF=7.666，中科院2区)

（7）Tianjiao Li#, Yi Zheng#, Tao Li, Ming Guo, Xiaodong Wu, Ruifang Liu, Qixiang Liu, Xueni You, Wenxian Zeng*, Yinghua Lv*. Potential dual protective effects of melatonin on spermatogonia against hexavalent chromium. Reproductive Toxicology. 2022, 111: 92-105. (#共同一作，IF=3.421)

（8）Zidong Liu#, Qiang Chen#, Xueni You, Xiaodong Wu, Ruifang Liu, Tao Li, Leilei Gao, Xiaoxu Chen, Anmin Lei*, Wenxian Zeng*, Yi Zheng*. Sperm-derived RNAs improve the efficiency of somatic cell nuclear transfer (SCNT) through promoting R-loop formation. Molecular Reproduction and Development. 2022, 89(8): 325-36. (*通讯作者，IF=2.812)

（9）Yi Zheng, Yuliang Liu, Rong Hou, Keyu Shi, Yijiao Chen, Tongying Feng, Junhui An*. Single-cell RNA-sequencing analysis and characterisation of testicular cells in giant panda (Ailuropoda melanoleuca). Reproduction Fertility and Development. 2022, 34(14): 933-43. (IF="1.973)

（10）Lingkai Zhang, Fuyuan Li, Peipei Lei, Ming Guo, Ruifang Liu, Ling Wang, Taiyong Yu, Yinghua Lv, Tao Zhang, Wenxian Zeng*, Hongzhao Lu*, Yi Zheng*. Single-cell RNA-sequencing reveals the dynamic process and novel markers in porcine spermatogenesis. Journal of Animal Science and Biotechnology. 2021, 12: 122. (*通讯作者，IF=6.175，中科院1区，Top期刊)

（11）Yinghua Lv#, Tianjiao Li#, Manman Yang, Lihong Su, Zhendong Zhu, Sihang Zhao, Wenxian Zeng*, Yi Zheng*. Melatonin attenuates chromium (VI)-induced spermatogonial stem cell/progenitor mitophagy by restoration of METTL3-mediated RNA N6-methyladenosine modification. Frontiers in Cell and Developmental Biology. 2021, 9: 684398. (*通讯作者，IF=6.081，中科院2区)

（12）Xiaoxu Chen#, Yi Zheng#*, Anmin Lei#, Hanxue Zhang, Huimin Niu, Xueliang Li, Pengfei Zhang, Mingzhi Liao, Yinghua Lv, Zhendong Zhu, Chuanying Pan, Wuzi Dong, Hong Chen, De Wu, Wansheng Liu, Geert Hamer, Shenming Zeng*, Wenxian Zeng*. Early cleavage of preimplantation embryos is regulated by tRNAGln-TTG-derived small RNAs present in mature spermatozoa. Journal of Biological Chemistry. 2020, 295(32): 10885-900. (#*共同一作、通讯作者，IF=5.486，中科院2区，自然指数期刊、Top期刊)

（13）Yi Zheng#, Tongying Feng#, Pengfei Zhang, Peipei Lei, Fuyuan Li, Wenxian Zeng*. Establishment of cell lines with porcine spermatogonial stem cell properties. Journal of Animal Science and Biotechnology. 2020, 11: 33. (IF="6.175，中科院1区，Top期刊)

（14）Pengfei Zhang#, Yi Zheng#*, Yinghua Lv, Fuyuan Li, Lihong Su, Yuwei Qin, Wenxian Zeng*. Melatonin protects the mouse testis against heat-induced damage. Molecular Human Reproduction. 2020, 26(2): 65-79. (#*共同一作、通讯作者，IF=4.518，中科院2区)

（15）Xueliang Li, Xiaoxu Chen, Yingdong Liu, Pengfei Zhang, Yi Zheng*, Wenxian Zeng*. The histone methyltransferase SETDB1 modulates survival of spermatogonial stem/progenitor cells through NADPH oxidase. Frontiers in Genetics. 2020, 11: 997. (*通讯作者，IF=4.772)

（16）Yi Zheng#, Pengfei Zhang#, Jinsheng Zhu#, Lingkai Zhang, Wenxian Zeng*. MicroRNA-382 inhibits the proliferation of mouse spermatogonia by targeting Kmt5a. Biocell. 2020, 44(2): 201-7. (IF="1.11)

（17）Yi Zheng#, Pengfei Zhang#, Conghui Zhang#, Wenxian Zeng*. Surgery-induced cryptorchidism induces apoptosis and autophagy of spermatogenic cells in mice. Zygote. 2019, 27(2): 101-10. (IF="1.818)

（18）Yi Zheng#, Qijing Lei#, Aldo Jongejan, Callista L Mulder, Saskia K M van Daalen, Sebastiaan Mastenbroek, Grace Hwang, Philip W Jordan, Sjoerd Repping, Geert Hamer*. The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair. 2018, 70: 55-66. (IF="4.354)

（19）Yi Zheng, Aldo Jongejan, Callista L Mulder, Sebastiaan Mastenbroek, Sjoerd Repping, Yinghua Wang, Jinsong Li, Geert Hamer*. Trivial role for NSMCE2 during in vitro proliferation and differentiation of male germline stem cells. Reproduction. 2017, 154(3): 181-95. (IF="3.923)

（20）Dideke E Verver#, Yi Zheng#, Dave Speijer, Ron Hoebe, Henk L Dekker, Sjoerd Repping, Jan Stap, Geert Hamer*. Non-SMC Element 2 (NSMCE2) of the SMC5/6 complex helps to resolve topological stress. International Journal of Molecular Sciences. 2016, 17(11): 1782. (#共同一作，IF=6.208，中科院2区，Top期刊)

（21）Yi Zheng, Yaqing Zhang, Rongfeng Qu, Ying He, Xiue Tian*, Wenxian Zeng*. Spermatogonial stem cells from domestic animals: progress and prospects. Reproduction. 2014, 147(3): R65-74. (IF="3.923)

（22）Yi Zheng#, Ying He#, Junhui An, Jinzhou Qin, Yihan Wang, Yaqing Zhang, Xiue Tian*, Wenxian Zeng*. THY1 is a surface marker of porcine gonocytes. Reproduction Fertility and Development. 2014, 26(4): 533-9. (IF="1.973)

（23）Yi Zheng, Xiue Tian, Yaqing Zhang, Jinzhou Qin, Junhui An, Wenxian Zeng*. In vitro propagation of male germline stem cells from piglets. Journal of Assisted Reproduction and Genetics. 2013, 30(7): 945-52. (IF="3.357)

（24）刘启祥, 吴志立, 魏永辉, 吕英华, 郑以*. 六价铬对雄性生殖机能的影响及治疗. 黑龙江动物繁殖. 2022, 30(04): 12-7, 23. (*通讯作者)

6. 联系方式

通讯地址：陕西省咸阳市杨凌区西农路22号西北农林科技大学3344体育在线官网535办公室

邮编：712100

E-mail：y.zheng@nwafu.edu.cn